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Since BB's damage is increased by diseases, yes it's very much worth it (+you'll get 2 dots on all targets).
If you're tanking remember that it's always good to throw up a DnD before you attempt to spread your diseases and during the first 3 GCD you wont be you any aoe threat so throwing in an DnD right before that should work..
However if you're trying to tank low health aoe targets then it's good to just drop DnD and BB right away (since they can die before your diseases spread.
Also, if you're frost/unholy then you might want to make sure to (if frost and without the HB glyph) DnD, IT ==> Pest ==> HB and they should stick to you like glue.
In the case of UH, DnD ==> diseases ==> pest ==> UB
2 Blood Boil will generate more threat/damage than 1 Diseased Blood Boil BUT the threat/damage that the diseases will generate make Diseased Blood Boil do more threat/damage in the end.
So basicaly it come down to: Do you want less but faster threat or more but slower threat.
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